"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T), and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).
Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
| IGHV subgroup |
IGHV gene name |
Fct | Breed | R | T | Pr | Reference sequences | Accession numbers | Sequences from the literature |
| IGHV1 | IGHV1-1 | P | (1) | ||||||
| IGHV1S1 | F | VHA | AF064686 [1] | ||||||
| IGHV1S2 | F | VHC | AF064688 [1] | ||||||
| IGHV1S3 | P (2) | VHI | AF064691 [1] | ||||||
| IGHV1S4 | F | VH2, VHB [2] | AF064687 [1] | ||||||
| VHB2 | |||||||||
| IGHV1S5 | F | VHE | AF064689 [1] | ||||||
| IGHV1S6 | F | VHF | AF064690 [1] | ||||||
| IGHV1S7 | P (3) | VHK | AF064692 [1] |
IMGT notes:
| (1) | IGHV1-1 is the most 3' IGHV in the locus. It is located 15 kb upstream of the IGHD genes [1, 2]. |
| (2) | INSERTION of 4 nucleotides (aaca at positions 440-443) and INSERTION of 1 nucleotide (a at position 492) in the FR3-IMGT. |
| (3) | No INIT-CODON and in frame STOP-CODON in the L-PART 1. |
Reference:
| [1] | Sun, J. et al., J.Immunol, 161,5070-5078 (1998). |
| [2] | Sun, J. and Butler J.E., Immunology, 88, 331-339 (1996). |
Created: 01/07/2002
Last updated: Monday, 22-Jan-2007 22:02:00 CET
Authors: Christèle Martinez-Jean and Delphine Guiraudou
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.
IMGT Repertoire (IG and TR)
IMGT Repertoire (MHC)
IMGT Repertoire (RPI)
IMGT Index
IMGT Scientific chart
IMGT Education
IMGT Home page
|
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
|
|
|
|
Citing IMGT © Copyright 1995-2010 IMGT®, the international ImMunoGeneTics information system® |
|||