Print of this table: Ruiz, M. et al., Exp. Clin. Immunogenet., 16, 173-184 (1999). PMID:10394055

Click here to see Part 2 - Human IGHD orphons on chromosome 15 (15q11.2)

• Fct: FUNCTIONALITY
• F: Functional
• P: Pseudogene
• ORF: Open Reading Frame
• vg: Vestigial

For a given gene name, each horizontal line corresponds to a different allele. For more information, see Alignments of alleles and Tables of alleles (IMGT Repertoire).

Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

IGHD subgroup	IGHD name	Fct	Reference sequences	Accession numbers	Position in X97051 (a)	Position in X97051 (b)	Sequences from the literature
1	IGHD1-1	F	D1-1	X97051 [8]	23599-35048	33686-33758	[AB019441][9]
	IGHD1-7	F	DM1	X13972/M37277 [5](1)	43057-44649	43272-43344	[X97051][8], [AB019441][9]
	IGHD1-14	ORF(2)	DM2	X13972/M37277 [5]	52325-53909	52540-52612	[X97051][8], [AB019441][9]
	IGHD1-20	F	D1-20	X97051 [8]	61770-63337	61987-62059	[AB019441][9]
	IGHD1-26	F	D1-26	X97051 [8]	71927-79765	72141-72216	[AB019441][9]
2	IGHD2-2	F	D4	J00232 [1]
		F	D2-2	X97051 [8]	35049-37615	36339-36425	[AB019441][9]
		F	D4	M35648 [3]			[M35649][3]
	IGHD2-8	F	DLR1	X13972/M37277 [5]	44650-47262	45954-46040	[X97051][8], [M35650][3], [AB019441][9]
		F	D1	J00233 [1]
	IGHD2-15	F	D2	J00234 [1]	53910-56408	55207-55293	[X97051][8], [AB019441][9]
	IGHD2-21	F	D3	J00235 [1]
		F	D2-21	X97051 [8]	63338-65916	64616-64699	[AB019441][9]
3	IGHD3-3	F	DXP4	X13972/M37277 [5]	37616-39425	38806-38892	[X97051][8], [AB019441][9]
		F	D23/7	X93618 [4]
	IGHD3-9	F	DXP1	X13972/M37277 [5]	47263-48619	48484-48570	[M37485][7], D21/0.5[X93613][4], [X97051][8], [AB019441][9]
	IGHD3-10	F	DXP'1	X13972/M37277 [5]	48620-49158	48668-48754	[M37485][7], [X97051][8], [AB019441][9]
		F	D21/7	X93615 [4]
	IGHD3-16	F	D21/10	X93614 [4]
		F		X97051 [9]	56409-58143	57524-57616	[AB019441][9]
	IGHD3-22	F	D21/9	X93616 [4]	65917-67762	67133-67219	[X97051][8], [AB019441][9]
4	IGHD4-4	F	DA4	X13972/M37277 [5]	39426-40474	39958-40029	[X97051][8], [AB019441][9]
	IGHD4-11	ORF(3)	DA1	X13972/M37277 [5]	49159-50078	49563-49634	[X97051][8], [AB019441][9]
	IGHD4-17	F	D4-17	X97051 [8]	58144-59187	58671-58742	[AB019441][9]
	IGHD4-23	ORF(3)	D4-23	X97051 [8]	67763-68826	68306-68380	[AB019441][9]
5	IGHD5-5	F	DK4	X13972/[M37277 [5]	40475-41880	40919-40994	[X97051][8], [AB019441][9]
	IGHD5-12	F	DK1	X13972/[M37277 [5]	50079-51316	50523-50601	[X97051][8], [AB019441][9]
	IGHD5-18	F	D5-18	X97051 [8]	59188-60591	59633-59708	[AB019441][9]
	IGHD5-24	ORF(4)	D5-24	X97051 [8]	68827-70492	69272-69347	[AB019441][9]
6	IGHD6-6	F	DN4	X13972/M37277 [5]	41881-43056	42767-42840	[X97051][8], [AB019441][9]
	IGHD6-13	F	DN1	X13972/M37277 [5]	51317-52324	52032-52108	[X97051][8], [AB019441][9]
	IGHD6-19	F	D6-19	X97051 [8]	60592-61769	61475-61551	[AB019441][9]
	IGHD6-25	F	D6-25	X97051 [8]	70493-71926	71638-71711	[AB019441][9]
7	IGHD7-27	F	DHQ52	J00256 [2]	87428-87515	87431-87497	[X97051][8], [X86355][6], [X86356][6], [X86357][6], [X86358][6], [X86359][6]

(a) Arbitrary limits of the DNA sequence assigned to the different D-GENEs
(b) Limits from the 5'D-NONAMER to the 3'D-NONAMER

IMGT notes:
(1) The original sequence is L13972 (14928 bp), M37277 (14929 bp) secondary accession number presents an INSERTION of one nucleotide C between positions 14587/14588 (in L13972), this INSERTION is after the coding region of the IGHD1-14, and do not concern the recombination signals either.
(2) ORF, because unusual 5'D HEPTAMER CACAGCG instead of CACAGTG.
(3) ORF, because unusual 5'D HEPTAMER TGCTGTG instead of CACAGTG.
(4) ORF, because unusual 5'D HEPTAMER GGCCGCG instead of CACAGTG.

References:

[1]	Siebenlist, U. et al., Nature, 294, 631-635 (1981).
[2]	Ravetch, J.V. et al., Cell, 27, 583-591 (1981).
[3]	Zong, S.Q. et al., Immunol. Lett., 17, 329-334 (1988).
[4]	Buluwela, L. et al., EMBO J., 7, 2003-2010 (1988).
[5]	Ichihara, Y. et al., EMBO J., 7, 4141-4150 (1988).
[6]	Mattila, P.S. et al., Eur. J. Immunol., 25, 2578-2582 (1995).
[7]	Huang, C. et al., Unpublished.
[8]	Corbett, S. et al., J. Mol. Biol., 270, 587-597 (1997).
[9]	Matsuda et al., J. Exp. Med., 188, 1-15 (1998).

Created: 18/04/1997
Last updated: Monday, 22-Jan-2007 22:01:56 CET
Authors: Dominique Scaviner, Manuel Ruiz
Contact: Marie-Paule Lefranc

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