The human TRA locus is located on chromosome 14 [1-3], on the long arm at band 14q11.2
The TRD locus is embedded in the TRA locus, between the TRAV and TRAJ genes (for detailed references, see [4]).
A vertical red line indicates the localization of the TRA and TRD loci at
14q11.2.
A blue arrow indicates the orientation 5' -> 3' of the loci, and the gene
group order in the loci. Note that the TRDV gene localized in 3' of the
TRDC gene is in inverted orientation of transcription (shown by a small
black arrow). The blue arrow is proportional to the total size of the
loci, indicated in kilobases (kb). The total number of genes in the TRA
and TRD loci is shown between parentheses.
The orientation of the locus has been determined by the analysis of translocations, involving the TRA and TRD loci, in leukemia and lymphoma.
| [1] | Collins, M.K.L. et al., EMBO J., 3, 2347-2349 (1984). |
| [2] | Croce, C. et al., Science, 227, 1044-1047 (1984). |
| [3] | Rabbitts, T.H. et al., EMBO J., 4, 1461-1465 (1985). |
| [4] | Lefranc, M.-P., Eur. Cytokine Net., 1, 121-130 (1990). |
Click here for a representation of the chromosome 14 showing both the TRA and TRD loci at 14q11.2, and the IGH locus at 14q32.33.