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Print of this table: Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 161-174 (2001). PMID:11549845 pdficon

The human IGK locus is located on chromosome 2 [1,2], on the short arm, at band 2p11.2 [3].

A vertical red line indicates the localization of the IGK locus at 2p11.2.
A blue arrow indicates the orientation 5' -> 3' of the locus, and the gene group order in the locus. The blue arrow is proportional to the size of the locus, indicated in kilobases (kb). The total number of genes in the locus is shown between parentheses; the lower number (46 genes) correspond to the rare haplotype which only comprises the proximal V-CLUSTER (close to IGKC) of 40 IGKV genes, whereas the higher number (82 genes) correspond to the common haplotype which comprise both the distal and the proximal V-CLUSTERs and 76 IGKV genes.

The orientation of the locus has been determined by the analysis of translocations, involving the IGK locus, in leukemia and lymphoma.

Human IGK chromosome 2
More information:
  1. IG and TR loci: Positions on chromosomes
  2. IGK locus representation
  3. IGK locus description
  4. Gene tables
  5. Potential germline repertoires
References:
[1] Malcolm, S. et al., Proc. Natl. Acad. Sci. USA, 79, 4957-4961 (1982).
[2] Mc Bride, O.W. et al., J. Exp. Med., 155, 1480-1490 (1982).
[3] Emanuel, B.S. et al., Proc. Natl. Acad. Sci. USA, 81, 2444-2446 (1984).