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Major histocompatibility complex (MHC)

Major histocompatibility complex (MHC) are proteins capable of presenting antigenic peptides, non-covalently bound in a groove to the T lymphocytes. The groove is formed by two G-DOMAINs which belong to the same chain (alpha chain of the MHC class I), or to two different chains (alpha and beta chains of the MHC class II). In the MHC class I, the alpha chain is associated to the beta2-microglobulin (B2M).

IMGT Education

• Position et orientation des gènes HLA-DR dans le locus MHC (in French)

IMGT Repertoire (MHC)

IMGT/3Dstructure-DB

IMGT Immunoinformatics page (IMGT Bloc-notes): Databases - Tools - Resources

• Major histocompatibility complex
• Peptides binding to MHC

Abbreviations:
MHC: Major histocompatibility complex
HLA: human MHC
H2: mouse MHC

GeneOntology:
GO:0042611 MHC protein complex

See also:

• Antibodies (or Immunoglobulins)
• B cell receptors
• Domain
• IMGT-ONTOLOGY
• T cell receptors

Created: 16/10/2003
Last udpated: Friday, 15-Jan-2010 17:12:50 CET
Author: Marie-Paule Lefranc
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc

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For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

     

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