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Génétique moléculaire des immunoglobulines

Figure 3 - Exemples de signaux de recombinaison de gènes V, D et J humain

Bien que les séquences heptamère et nonamère sont bien conservées, il y a des différences de séquences entre les gènes individuels. Les longueurs des espaceurs sont de 12±1 ou 23±1 bp (observation décrite sous le nom de règle 12/23) [Early P. et al. Cell 19, 981-992 (1980), PMID: 6769593]

Created: 30/05/2001
Last updated: Friday, 15-Jan-2010 17:12:50 CET
Authors: Elodie Foulquier and Marie-Paule Lefranc
Editors: Céline Protat and Chantal Ginestoux
Contact: Marie-Paule Lefranc

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