Antibody engineering

Combinatorial libraries & phage displays

• Présentation à la surface de phages filamenteux : les multiples applications du phage display

Reagents monoclonal antibodies

• T cell receptors
  • TRAV: Human
  • TRBV: Human
  • TRGV: Human
  • TRDV: Human
• Human proteins associated with cancer
  • Clinical Proteomic Technologies for Cancer (CPTC) Reagent Data Portal, National Cancer Institute, provides standard operating procedures (SOPs) and characterized monoclonal antibodies to human proteins associated with cancer.

Antibody humanization

CAMPATH-1H (Humanized antibodies)

• Protein display V-DOMAIN:
  • IGH
  • IGK
• Colliers de Perles:
  • IGH
  • IGK
• 3D representation

K20 (Humanized antibodies)

• Protein display V-DOMAIN:
  • IGH
  • IGK
• Colliers de Perles:
  • IGH
  • IGK

FR-IMGT and CDR-IMGT

• FR-IMGT lengths for comparison of humanized antibodies

Antibody camelization

• IMGT/3Dstructure-DB:
  • Camelized
• IMGT Veterinary page:
  • Camel
  • Llama
• Characteristics of the camelidae (camel, llama) antibody synthesis

Monoclonal antibodies with clinical indications

• Monoclonal antibodies
  • Murine monoclonal antibodies
  • Rat monoclonal antibodies
  • Chimeric monoclonal antibodies
  • Humanized monoclonal antibodies
  • Human monoclonal antibodies
  • Immunotoxins
  • Immunoadhesins
  • Bispecific antibodies

External links and resources

• Drugs@FDA, FDA drug approved products
• New Drug Approvals, Drug information online, Drugs.com
• WHO Lists of Recommended and Proposed INNs
• WHO International Nonproprietary Names
  • International Nonproprietary Names (INN) Publications
  • International Nonproprietary Names (INN) Working Group Meeting on Nomenclature for Monoclonal Antibodies (mAb), Geneva, 6-7 October 2008, INN Working Doc. 08.242
  • General policies for monoclonal antibodies, World Health Organization (WHO). International Nonproprietary Names (INN) Working Document 09.251, 24/06/2009